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2022

Laminin N-terminus α31 is upregulated in invasive ductal breast cancer and changes the mode of tumour invasion. Troughton LD, O'Loughlin DA, Zech T, Hamill KJ.PLoS One. 2022 Mar 1;17(3):e0264430. doi: 10.1371/journal.pone.0264430. PMID: 35231053; PMCID: PMC8887744.

Inhibition of Protein N-Glycosylation Blocks SARS-CoV-2 Infection. Casas-Sanchez A, Romero-Ramirez A, Hargreaves E, Ellis CC, Grajeda BI, Estevao IL, Patterson EI, Hughes GL, Almeida IC, Zech T, Acosta-Serrano Á. mBio. 2022 Feb 15;13(1):e0371821. doi: 10.1128/mbio.03718-21. Epub ahead of print. PMID: 35164559; PMCID: PMC8844921.

 

2021

Cells in Slow Motion: Apparent Undercooling Increases Glassy Behavior at Physiological Temperatures

Schnauß J, Kunschmann T, Grosser S, Mollenkopf P, Zech T, Freitag JS, Prascevic D, Stange R, Röttger LS, Rönicke S, Smith DM, Bayerl TM, Käs JA.

Advanced Materials, 2021, 33(29), 2101840

3D matrix adhesion composition facilitates nuclear force coupling to drive invasive cell migration D Newman, L Young, T Waring, L Brown, K Wolanska, E MacDonald, ... Zech T

 https://www.biorxiv.org/content/10.1101/2021.05.17.443835v1

Protein N-glycosylation is essential for SARS-CoV-2 infection

Aitor Casas-Sanchez, Alessandra Romero-Ramirez, Eleanor Hargreaves, Cameron C. Ellis, Brian I. Grajeda, Igor Estevao, Edward I. Patterson, Grant L. Hughes, Igor C. Almeida, Tobias Zech, Álvaro Acosta-Serrano

https://www.biorxiv.org/content/10.1101/2021.02.05.429940v2

2020

Connecting the dots: combined control of endocytic recycling and degradation. MacDonald E  Savage B, Zech T. Biochem Soc Trans. 2020 Dec 10;48(6):2377-86.

Laminin N-terminus α31 is upregulated in invasive ductal breast cancer and changes the mode of tumour invasion

LD Troughton, T Zech, KJ Hamill

 https://www.biorxiv.org/content/10.1101/2020.05.28.120964v1.full

2019
Memen

M embrane Tension Orchestrates Rear Retraction in Matrix-Directed Cell Migration.

Hetmanski JHR, de Belly H, Busnelli I, Waring T, Nair RV, Sokleva V, Dobre O, Cameron A, Gauthier N, Lamaze C, Swift J, Del Campo A, Starborg T, Zech T, Goetz JG, Paluch EK, Schwartz JM, Caswell PT.  Dev Cell. 2019 Nov 18;51(4):460-475

Local actin nucleation tunes centrosomal microtubule nucleation during passage through mitosis 

Farina F, Ramkumar N, Brown L, Samandar-Eweis D, Anstatt J, Waring T, Bithell J, Scita G, Thery M, Blanchoin L, Zech T, Baum B EMBO J. 2019 Jun 3;38(11) Published online 2019 Apr 23. doi: 10.15252/embj.201899843
 

2018

 A splicing switch provides dual layer control of laminin alpha3: Implications for squamous cell carcinoma.

Troughton, L. D., Barrera, V., Brown, L., Zech, T., Willoughby, C. E., Risk, J. M., & Hamill, K. J. (2018). In JOURNAL OF INVESTIGATIVE DERMATOLOGY Vol. 138 (pp. S147). Retrieved from http://gateway.webofknowledge.com/
 

Actin-Based Cell Protrusion in a 3D Matrix (Journal article)

Caswell, P. T., & Zech, T. (2018). Actin-Basec Cell Protrusion in a 3D Matrix. TRENDS IN CELL BIOLOGY, 28(10), 823-834. doi:10.1016/j.tcb.2018.06.003

DOI: 10.1016/j.tcb.2018.06.003
 

Cell Scientist to Watch - Tobias Zech (Journal article)

Zech, T. (2018). Cell Scientist to Watch - Tobias Zech. JOURNAL OF CELL SCIENCE, 131(22). doi:10.1242/jcs.227223

DOI: 10.1242/jcs.227223
 

HRS-WASH axis governs actin-mediated endosomal recycling and cell invasion (Journal article)

MacDonald, E., Brown, L., Selvais, A., Liu, H., Waring, T., Newman, D., . . . Zech, T. (2018). HRS-WASH axis governs actin-mediated endosomal recycling and cell invasion. JOURNAL OF CELL BIOLOGY, 217(7), 2549-2564. doi:10.1083/jcb.201710051

DOI: 10.1083/jcb.201710051
 

STEF/TIAM2-mediated Rac1 activity at the nuclear envelope regulates the perinuclear actin cap (Journal article)

Woroniuk, A., Porter, A., White, G., Newman, D. T., Diamantopoulou, Z., Waring, T., . . . Malliri, A. (2018). STEF/TIAM2-mediated Rac1 activity at the nuclear envelope regulates the perinuclear actin cap. NATURE COMMUNICATIONS, 9. doi:10.1038/s41467-018-04404-4

DOI: 10.1038/s41467-018-04404-4
 

2016

WIP and WICH/WIRE co-ordinately control invadopodium formation and maturation in human breast cancer cell invasion (Journal article)

Garcia, E., Ragazzini, C., Yu, X., Cuesta-Garcia, E., de la Serna, J. B., Zech, T., . . . Anton, I. M. (2016). WIP and WICH/WIRE co-ordinately control invadopodium formation and maturation in human breast cancer cell invasion. SCIENTIFIC REPORTS, 6. doi:10.1038/srep23590

DOI: 10.1038/srep23590
 

2014

PIKfyve, MTMR3 and their product PtdIns5P regulate cancer cell migration and invasion through activation of Rac1 (Journal article)

Oppelt, A., Haugsten, E. M., Zech, T., Danielsen, H. E., Sveen, A., Lobert, V. H., . . . Wesche, J. (2014). PIKfyve, MTMR3 and their product PtdIns5P regulate cancer cell migration and invasion through activation of Rac1. BIOCHEMICAL JOURNAL, 461, 383-390. doi:10.1042/BJ20140132


 

2013

Cyclical Action of the WASH Complex: FAM21 and Capping Protein Drive WASH Recycling, Not Initial Recruitment (Journal article)

Park, L., Thomason, P. A., Zech, T., King, J. S., Veltman, D. M., Carnell, M., . . . Insall, R. H. (2013). Cyclical Action of the WASH Complex: FAM21 and Capping Protein Drive WASH Recycling, Not Initial Recruitment. DEVELOPMENTAL CELL, 24(2), 169-181. 

DOI: 10.1016/j.devce1.2012.12.014
 

Loss of Scar/WAVE Complex Promotes N-WASP- and FAK-Dependent Invasion (Journal article)

Tang, H., Li, A., Bi, J., Veltman, D. M., Zech, T., Spence, H. J., . . . Machesky, L. M. (2013). Loss of Scar/WAVE Complex Promotes N-WASP- and FAK-Dependent Invasion. CURRENT BIOLOGY, 23(2), 107-117. doi:10.1016/j.cub.2012.11.059

DOI: 10.1016/j.cub.2012.11.059
 

2012

Actin on trafficking Could actin guide directed receptor transport? (Journal article)

Zech, T., Calaminus, S. D. J., & Machesky, L. M. (2012). Actin on trafficking Could actin guide directed receptor transport?. CELL ADHESION & MIGRATION, 6(6), 476-481. 

DOI: 10.4161/cam.21373
 

Gadkin negatively regulates cell spreading and motility via sequestration of the actin-nucleating ARP2/3 complex (Journal article)

Maritzen, T., Zech, T., Schmidt, M. R., Krause, E., Machesky, L. M., & Haucke, V. (2012). Gadkin negatively regulates cell spreading and motility via sequestration of the actin-nucleating ARP2/3 complex. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 109(26), 10382-10387. doi:10.1073/pnas.1206468109

DOI: 10.1073/pnas.1206468109

N-WASP coordinates the delivery and F-actin-mediated capture of MT1-MMP at invasive pseudopods (Journal article)
 

Yu, X., Zech, T., McDonald, L., Garcia Gonzalez, E., Li, A., Macpherson, I., . . . Machesky, L. M. (2012). N-WASP coordinates the delivery and F-actin-mediated capture of MT1-MMP at invasive pseudopods. JOURNAL OF CELL BIOLOGY, 199(3), 527-544. doi:10.1083/jcb.201203025

DOI: 10.1083/jcb.201203025

2011

Actin polymerization driven by WASH causes V-ATPase retrieval and vesicle neutralization before exocytosis (Journal article)

Carnell, M., Zech, T., Calaminus, S. D., Ura, S., Hagedorn, M., Johnston, S. A., . . . Insall, R. H. (2011). Actin polymerization driven by WASH causes V-ATPase retrieval and vesicle neutralization before exocytosis. JOURNAL OF CELL BIOLOGY, 193(5), 831-839. doi:10.1083/jcb.201009119

DOI: 10.1083/jcb.201009119
 

Proteomic Characterization of Plasma Membrane-proximal T Cell Activation Responses (Journal article)

de Wet, B., Zech, T., Salek, M., Acuto, O., & Harder, T. (2011). Proteomic Characterization of Plasma Membrane-proximal T Cell Activation Responses. JOURNAL OF BIOLOGICAL CHEMISTRY, 286(6), 4072-4080. doi:10.1074/jbc.M110.165415

DOI: 10.1074/jbc.M110.165415
 

The Arp2/3 activator WASH regulates alpha 5 beta 1-integrin-mediated invasive migration (Journal article)

Zech, T., Calaminus, S. D. J., Caswell, P., Spence, H. J., Carnell, M., Insall, R. H., . . . Machesky, L. M. (2011). The Arp2/3 activator WASH regulates alpha 5 beta 1-integrin-mediated invasive migration. JOURNAL OF CELL SCIENCE, 124(22), 3753-3759. doi:10.1242/jcs.080986

DOI: 10.1242/jcs.080986

Tobi has been doing science for a long time. For pre-2009 publications please see Tobi's publications here, and two of note below:

Accumulation of raft lipids in T-cell plasma membrane domains engaged in TCR signalling 

Zech, T., Ejsing, C. S., Gaus, K., de Wet, B., Shevchenko, A., Simons, K., & Harder, T. (2009). Accumulation of raft lipids in T-cell plasma membrane domains engaged in TCR signalling. EMBO JOURNAL, 28(5), 466-476. doi:10.1038/emboj.2009.6

 

Functional implications of plasma membrane condensation for T cell activation.

Rentero, C., Zech, T., Quinn, C. M., Engelhardt, K., Williamson, D., Grewal, T., . . . Gaus, K. (2008). Functional implications of plasma membrane condensation for T cell activation.. PloS one, 3(5), e2262. doi:10.1371/journal.pone.0002262

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