2022
Laminin N-terminus α31 is upregulated in invasive ductal breast cancer and changes the mode of tumour invasion. Troughton LD, O'Loughlin DA, Zech T, Hamill KJ.PLoS One. 2022 Mar 1;17(3):e0264430. doi: 10.1371/journal.pone.0264430. PMID: 35231053; PMCID: PMC8887744.
Inhibition of Protein N-Glycosylation Blocks SARS-CoV-2 Infection. Casas-Sanchez A, Romero-Ramirez A, Hargreaves E, Ellis CC, Grajeda BI, Estevao IL, Patterson EI, Hughes GL, Almeida IC, Zech T, Acosta-Serrano Á. mBio. 2022 Feb 15;13(1):e0371821. doi: 10.1128/mbio.03718-21. Epub ahead of print. PMID: 35164559; PMCID: PMC8844921.
2021
Cells in Slow Motion: Apparent Undercooling Increases Glassy Behavior at Physiological Temperatures
Advanced Materials, 2021, 33(29), 2101840
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3D matrix adhesion composition facilitates nuclear force coupling to drive invasive cell migration D Newman, L Young, T Waring, L Brown, K Wolanska, E MacDonald, ... Zech T
https://www.biorxiv.org/content/10.1101/2021.05.17.443835v1
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Protein N-glycosylation is essential for SARS-CoV-2 infection
Aitor Casas-Sanchez, Alessandra Romero-Ramirez, Eleanor Hargreaves, Cameron C. Ellis, Brian I. Grajeda, Igor Estevao, Edward I. Patterson, Grant L. Hughes, Igor C. Almeida, Tobias Zech, Álvaro Acosta-Serrano
https://www.biorxiv.org/content/10.1101/2021.02.05.429940v2
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2020
Connecting the dots: combined control of endocytic recycling and degradation. MacDonald E Savage B, Zech T. Biochem Soc Trans. 2020 Dec 10;48(6):2377-86.
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LD Troughton, T Zech, KJ Hamill
https://www.biorxiv.org/content/10.1101/2020.05.28.120964v1.full
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2019
Memen
M embrane Tension Orchestrates Rear Retraction in Matrix-Directed Cell Migration.
Hetmanski JHR, de Belly H, Busnelli I, Waring T, Nair RV, Sokleva V, Dobre O, Cameron A, Gauthier N, Lamaze C, Swift J, Del Campo A, Starborg T, Zech T, Goetz JG, Paluch EK, Schwartz JM, Caswell PT. Dev Cell. 2019 Nov 18;51(4):460-475
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Local actin nucleation tunes centrosomal microtubule nucleation during passage through mitosis
Farina F, Ramkumar N, Brown L, Samandar-Eweis D, Anstatt J, Waring T, Bithell J, Scita G, Thery M, Blanchoin L, Zech T, Baum B EMBO J. 2019 Jun 3;38(11) Published online 2019 Apr 23. doi: 10.15252/embj.201899843​
2018
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A splicing switch provides dual layer control of laminin alpha3: Implications for squamous cell carcinoma.
Troughton, L. D., Barrera, V., Brown, L., Zech, T., Willoughby, C. E., Risk, J. M., & Hamill, K. J. (2018). In JOURNAL OF INVESTIGATIVE DERMATOLOGY Vol. 138 (pp. S147). Retrieved from http://gateway.webofknowledge.com/
Actin-Based Cell Protrusion in a 3D Matrix (Journal article)
Caswell, P. T., & Zech, T. (2018). Actin-Basec Cell Protrusion in a 3D Matrix. TRENDS IN CELL BIOLOGY, 28(10), 823-834. doi:10.1016/j.tcb.2018.06.003
DOI: 10.1016/j.tcb.2018.06.003
Cell Scientist to Watch - Tobias Zech (Journal article)
Zech, T. (2018). Cell Scientist to Watch - Tobias Zech. JOURNAL OF CELL SCIENCE, 131(22). doi:10.1242/jcs.227223
HRS-WASH axis governs actin-mediated endosomal recycling and cell invasion (Journal article)
MacDonald, E., Brown, L., Selvais, A., Liu, H., Waring, T., Newman, D., . . . Zech, T. (2018). HRS-WASH axis governs actin-mediated endosomal recycling and cell invasion. JOURNAL OF CELL BIOLOGY, 217(7), 2549-2564. doi:10.1083/jcb.201710051
STEF/TIAM2-mediated Rac1 activity at the nuclear envelope regulates the perinuclear actin cap (Journal article)
Woroniuk, A., Porter, A., White, G., Newman, D. T., Diamantopoulou, Z., Waring, T., . . . Malliri, A. (2018). STEF/TIAM2-mediated Rac1 activity at the nuclear envelope regulates the perinuclear actin cap. NATURE COMMUNICATIONS, 9. doi:10.1038/s41467-018-04404-4
DOI: 10.1038/s41467-018-04404-4
2016
WIP and WICH/WIRE co-ordinately control invadopodium formation and maturation in human breast cancer cell invasion (Journal article)
Garcia, E., Ragazzini, C., Yu, X., Cuesta-Garcia, E., de la Serna, J. B., Zech, T., . . . Anton, I. M. (2016). WIP and WICH/WIRE co-ordinately control invadopodium formation and maturation in human breast cancer cell invasion. SCIENTIFIC REPORTS, 6. doi:10.1038/srep23590
2014
PIKfyve, MTMR3 and their product PtdIns5P regulate cancer cell migration and invasion through activation of Rac1 (Journal article)
Oppelt, A., Haugsten, E. M., Zech, T., Danielsen, H. E., Sveen, A., Lobert, V. H., . . . Wesche, J. (2014). PIKfyve, MTMR3 and their product PtdIns5P regulate cancer cell migration and invasion through activation of Rac1. BIOCHEMICAL JOURNAL, 461, 383-390. doi:10.1042/BJ20140132
2013
Cyclical Action of the WASH Complex: FAM21 and Capping Protein Drive WASH Recycling, Not Initial Recruitment (Journal article)
Park, L., Thomason, P. A., Zech, T., King, J. S., Veltman, D. M., Carnell, M., . . . Insall, R. H. (2013). Cyclical Action of the WASH Complex: FAM21 and Capping Protein Drive WASH Recycling, Not Initial Recruitment. DEVELOPMENTAL CELL, 24(2), 169-181.
DOI: 10.1016/j.devce1.2012.12.014
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Loss of Scar/WAVE Complex Promotes N-WASP- and FAK-Dependent Invasion (Journal article)
Tang, H., Li, A., Bi, J., Veltman, D. M., Zech, T., Spence, H. J., . . . Machesky, L. M. (2013). Loss of Scar/WAVE Complex Promotes N-WASP- and FAK-Dependent Invasion. CURRENT BIOLOGY, 23(2), 107-117. doi:10.1016/j.cub.2012.11.059
DOI: 10.1016/j.cub.2012.11.059
2012
Actin on trafficking Could actin guide directed receptor transport? (Journal article)
Zech, T., Calaminus, S. D. J., & Machesky, L. M. (2012). Actin on trafficking Could actin guide directed receptor transport?. CELL ADHESION & MIGRATION, 6(6), 476-481.
Gadkin negatively regulates cell spreading and motility via sequestration of the actin-nucleating ARP2/3 complex (Journal article)
Maritzen, T., Zech, T., Schmidt, M. R., Krause, E., Machesky, L. M., & Haucke, V. (2012). Gadkin negatively regulates cell spreading and motility via sequestration of the actin-nucleating ARP2/3 complex. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 109(26), 10382-10387. doi:10.1073/pnas.1206468109
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N-WASP coordinates the delivery and F-actin-mediated capture of MT1-MMP at invasive pseudopods (Journal article)
Yu, X., Zech, T., McDonald, L., Garcia Gonzalez, E., Li, A., Macpherson, I., . . . Machesky, L. M. (2012). N-WASP coordinates the delivery and F-actin-mediated capture of MT1-MMP at invasive pseudopods. JOURNAL OF CELL BIOLOGY, 199(3), 527-544. doi:10.1083/jcb.201203025
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2011
Actin polymerization driven by WASH causes V-ATPase retrieval and vesicle neutralization before exocytosis (Journal article)
Carnell, M., Zech, T., Calaminus, S. D., Ura, S., Hagedorn, M., Johnston, S. A., . . . Insall, R. H. (2011). Actin polymerization driven by WASH causes V-ATPase retrieval and vesicle neutralization before exocytosis. JOURNAL OF CELL BIOLOGY, 193(5), 831-839. doi:10.1083/jcb.201009119
Proteomic Characterization of Plasma Membrane-proximal T Cell Activation Responses (Journal article)
de Wet, B., Zech, T., Salek, M., Acuto, O., & Harder, T. (2011). Proteomic Characterization of Plasma Membrane-proximal T Cell Activation Responses. JOURNAL OF BIOLOGICAL CHEMISTRY, 286(6), 4072-4080. doi:10.1074/jbc.M110.165415
The Arp2/3 activator WASH regulates alpha 5 beta 1-integrin-mediated invasive migration (Journal article)
Zech, T., Calaminus, S. D. J., Caswell, P., Spence, H. J., Carnell, M., Insall, R. H., . . . Machesky, L. M. (2011). The Arp2/3 activator WASH regulates alpha 5 beta 1-integrin-mediated invasive migration. JOURNAL OF CELL SCIENCE, 124(22), 3753-3759. doi:10.1242/jcs.080986
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Tobi has been doing science for a long time. For pre-2009 publications please see Tobi's publications here, and two of note below:
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Accumulation of raft lipids in T-cell plasma membrane domains engaged in TCR signalling
Zech, T., Ejsing, C. S., Gaus, K., de Wet, B., Shevchenko, A., Simons, K., & Harder, T. (2009). Accumulation of raft lipids in T-cell plasma membrane domains engaged in TCR signalling. EMBO JOURNAL, 28(5), 466-476. doi:10.1038/emboj.2009.6
Functional implications of plasma membrane condensation for T cell activation.
Rentero, C., Zech, T., Quinn, C. M., Engelhardt, K., Williamson, D., Grewal, T., . . . Gaus, K. (2008). Functional implications of plasma membrane condensation for T cell activation.. PloS one, 3(5), e2262. doi:10.1371/journal.pone.0002262