Actin contributes to vesicular trafficking, acting as a molecular scaffold, providing force to deform membranes, facilitating vesicle abscission or propelling a vesicle through the cytoplasm and recent studies highlight important connections between the directed trafficking of receptors and the impact on cell migration and actin dynamics. A number of newly described actin nucleation promoting factors, such as the vesicle associated protein WASH, reveal unexpected roles of actin in membrane traffic and suggest that the cell dedicates a significant proportion of its regulation of actin dynamics to controlling trafficking. We are currently identifying the biological functions of vesicular actin in receptor trafficking. Our research can show that WASH mediated actin binding of receptors on endosomal membranes dictates their trafficking route towards recycling to the plasma membrane, away from ESCRT complex mediated receptor degradation pathways. This has important implications for receptor kinase driven tumors, like Her2 positive breast cancer, since the mechanism that recycles Her2 to the cell surface is pivotal for tumor progression and deregulated in drug resistance. We hope that by investigating WASH mediated receptor recycling we will find novel ways to target Her2 positive breast cancer.